To Keep Acrylic Nails Clean, you have to use gloves once doing chores around the house. After that, Scrub your nails with a nail brush and antibacterial soap at least once a day. You need to Scrub under the nails as well as scrubbing the tops. Then, Wash your hands regularly with antibacterial soap throughout the day to keep your hands and nails sanitized. You must ensure that you dry your hands and under your nails thoroughly once you are finished washing them. Next, keep a nail brush with you when you leave home.